Semaglutide vs Tirzepatide — detailed comparison for 202613 April 2026|PeptidLabs Teamsemaglutidetirzepatideweight-losscomparisonSemaglutide and Tirzepatide dominate metabolic research. Both work via the incretin system but differ. Semaglutide — pure GLP-1 agonist Activates only GLP-1 receptors Thousands of published studies Tirzepatide — dual GLP-1/GIP agonist Activates both receptors Stronger metabolic effect in studies