What is the "SURMOUNT titration" protocol for Tirzepatide?

2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg · 1× weekly · 20 weeks titration + 52 weeks maintenance

Dosing

Tirzepatide (Mounjaro, Zepbound) - dosing protocol

Tirzepatide (dual agonist of GLP-1, hormone that reduces appetite, and GIP, hormone that improves insulin sensitivity) starts at 2.5 mg under the skin (s.c. injection) weekly for 4 weeks, then increases by 2.5 mg every 4 weeks up to target 5-15 mg. SURMOUNT-1 shows 22.5% weight loss over 72 weeks at 15 mg.

Route

Subcutaneous (s.c.)

Dose

2.5-15 mg / weekly

Half-life

~5 days

Storage

-20°C lyophilized; reconstituted — 21-28 days at 2-8°C

Dosing regimens

Standard regimens from the literature. The choice depends on what you're trying to achieve.

Protocol

SURMOUNT titration

Dose: 2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg
Frequency: 1× weekly
Duration: 20 weeks titration + 52 weeks maintenance

Side effects

Side-effect profile resembles Semaglutide but with slightly higher nausea and diarrhea rates due to added GIP (hormone that improves insulin sensitivity) activation. SURMOUNT-1 reports transient gastrointestinal signal in 60-70% of participants during the first 12 weeks.

See full side-effect list

Encyclopedia

Full scientific profile for Tirzepatide

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Last reviewed: 6 May 2026by PeptidLabs Editorial