Comparison

LiraglutideCagrilintide

Both are metabolic but target different receptors. Liraglutide is first-generation GLP-1 (Saxenda/Victoza, FDA 2010). Cagrilintide is a long-acting amylin analog — a new mechanism category, developed as a Semaglutide partner (CagriSema).

Spec	A Liraglutide	B Cagrilintide
Receptor	GLP-1R	Amylin (CTR/RAMP)
Generation	First-gen GLP-1 (2010)	First long-acting amylin (2024)
Manufacturer	Novo Nordisk	Novo Nordisk
FDA status	Approved (Saxenda 2014, Victoza 2010)	Phase 3 (REDEFINE trials)
Dosing	1.8-3.0 mg s.c. daily	2.4 mg s.c. 1× weekly
Half-life	~13 hours	~7 days
Weight loss (mono)	~8% / 56 weeks (SCALE)	~10% / 26 weeks (Phase 2)
In combination	Doesn't stack with other GLP-1s	CagriSema (+ Semaglutide) → 22% / 32 weeks

Choose A when

Liraglutide

Established GLP-1 with long history (15+ years) but requires daily injection. Cheaper than newer GLP-1s.

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Choose B when

Cagrilintide

Novel mechanism category. The real strength is the Semaglutide stack (CagriSema) — strongest Phase 2 weight loss to date.

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Verdict

Liraglutide is an aging classic; Cagrilintide is the new addition, especially when stacked with GLP-1. Not direct substitutes — different receptors.

Other comparisons

Keep exploring

Semaglutide vs Tirzepatide

Semaglutide vs Retatrutide

Tirzepatide vs Retatrutide

BPC-157 vs TB-500

Last reviewed: 6 May 2026by PeptidLabs Editorial

Comparison

LiraglutideCagrilintide

Spec	A Liraglutide	B Cagrilintide
Receptor	GLP-1R	Amylin (CTR/RAMP)
Generation	First-gen GLP-1 (2010)	First long-acting amylin (2024)
Manufacturer	Novo Nordisk	Novo Nordisk
FDA status	Approved (Saxenda 2014, Victoza 2010)	Phase 3 (REDEFINE trials)
Dosing	1.8-3.0 mg s.c. daily	2.4 mg s.c. 1× weekly
Half-life	~13 hours	~7 days
Weight loss (mono)	~8% / 56 weeks (SCALE)	~10% / 26 weeks (Phase 2)
In combination	Doesn't stack with other GLP-1s	CagriSema (+ Semaglutide) → 22% / 32 weeks

Choose A when

Liraglutide

Established GLP-1 with long history (15+ years) but requires daily injection. Cheaper than newer GLP-1s.

See full profile

Choose B when

Cagrilintide

Novel mechanism category. The real strength is the Semaglutide stack (CagriSema) — strongest Phase 2 weight loss to date.

See full profile

Verdict

Liraglutide is an aging classic; Cagrilintide is the new addition, especially when stacked with GLP-1. Not direct substitutes — different receptors.

Other comparisons

Keep exploring

Semaglutide vs Tirzepatide

Semaglutide vs Retatrutide

Tirzepatide vs Retatrutide

BPC-157 vs TB-500

Last reviewed: 6 May 2026by PeptidLabs Editorial