What is the "TRIUMPH titration" protocol for Retatrutide?

2 → 4 → 6 → 8 → 10 → 12 mg · 1× weekly · 24 weeks titration + 24+ weeks maintenance

Dosing

Retatrutide (triple agonist) - dosing protocol

Retatrutide (triple agonist of GLP-1, hormone that reduces appetite, GIP, hormone that improves insulin sensitivity, and glucagon; Phase 3) titrates from 2 mg under the skin (s.c. injection) weekly, increasing by 2 mg every 4 weeks to target 8-12 mg. Phase 2 NEJM 2023 shows 24.2% weight loss over 48 weeks at 12 mg.

Route

Subcutaneous (s.c.)

Dose

2-12 mg / weekly

Half-life

~6 days

Storage

-20°C lyophilized; reconstituted — 28 days at 2-8°C

Dosing regimens

Standard regimens from the literature. The choice depends on what you're trying to achieve.

Protocol

TRIUMPH titration

Dose: 2 → 4 → 6 → 8 → 10 → 12 mg
Frequency: 1× weekly
Duration: 24 weeks titration + 24+ weeks maintenance

Side effects

The triple mechanism — GLP-1 (hormone that reduces appetite) + GIP (hormone that improves insulin sensitivity) + glucagon — adds higher heart rate (from the glucagon component) on top of the usual gastrointestinal profile. Phase 2 reports a transient 5-7 bpm increase at higher doses.

See full side-effect list

Encyclopedia

Full scientific profile for Retatrutide

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Last reviewed: 6 May 2026by PeptidLabs Editorial