How common is "Nausea" with Retatrutide?

common, moderate - Phase 2 NEJM 2023.

Side effects

Retatrutide (triple agonist) - side effects

The triple mechanism — GLP-1 (hormone that reduces appetite) + GIP (hormone that improves insulin sensitivity) + glucagon — adds higher heart rate (from the glucagon component) on top of the usual gastrointestinal profile. Phase 2 reports a transient 5-7 bpm increase at higher doses.

Documented effects

Sorted by severity. Source cited when published.

Nausea

moderate·common·Phase 2 NEJM 2023

Diarrhea

moderate·common

Vomiting

moderate·common

Transient heart rate increase (5-7 bpm)

mild·common·Phase 2

Constipation

mild·common

Dosing

Retatrutide dosing protocol

Encyclopedia

Full scientific profile for Retatrutide

Disclaimer: data is curated from research literature for in-vitro experiments. This is not medical advice.

Last reviewed: 6 May 2026by PeptidLabs Editorial

Side effects

Retatrutide (triple agonist) - side effects

Documented effects

Sorted by severity. Source cited when published.

Nausea

moderate·common·Phase 2 NEJM 2023

Diarrhea

moderate·common

Vomiting

moderate·common

Transient heart rate increase (5-7 bpm)

mild·common·Phase 2

Constipation

mild·common

Dosing

Retatrutide dosing protocol

Encyclopedia

Full scientific profile for Retatrutide

Disclaimer: data is curated from research literature for in-vitro experiments. This is not medical advice.

Last reviewed: 6 May 2026by PeptidLabs Editorial