What is the "Standard STEP titration" protocol for Semaglutide?

0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg · 1× weekly s.c. · 16 weeks titration + 52 weeks maintenance

What is the "SUSTAIN (diabetes) protocol" protocol for Semaglutide?

0.5-1.0 mg · 1× weekly · Long-term

Dosing

Semaglutide (Ozempic, Wegovy) - dosing protocol

Semaglutide (GLP-1, hormone that reduces appetite) titrates slowly: 0.25 mg under the skin (s.c. injection) weekly for 4 weeks, 0.5 mg for next 4, then increase to 1.0-2.4 mg weekly. STEP protocols test up to 2.4 mg — mean 14.9% weight loss over 68 weeks.

Route

Subcutaneous (s.c.) — abdomen, thigh, or upper arm

Dose

0.25-2.4 mg / weekly

Half-life

~7 days

Storage

2-8°C lyophilized; reconstituted — 28 days at 2-8°C

Dosing regimens

Standard regimens from the literature. The choice depends on what you're trying to achieve.

Protocol

Standard STEP titration

Dose: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg
Frequency: 1× weekly s.c.
Duration: 16 weeks titration + 52 weeks maintenance

Protocol

SUSTAIN (diabetes) protocol

Dose: 0.5-1.0 mg
Frequency: 1× weekly
Duration: Long-term

Side effects

Gastrointestinal (stomach-and-gut) side effects dominate the profile — nausea (44%), vomiting (24%), diarrhea (30%), and constipation (24%) in STEP 1. Most resolve over 8-12 weeks and are dose-dependent. Slow titration significantly reduces severity.

See full side-effect list

Encyclopedia

Full scientific profile for Semaglutide

Calculator

What does this protocol cost per day?

Last reviewed: 6 May 2026by PeptidLabs Editorial

Dosing

Semaglutide (Ozempic, Wegovy) - dosing protocol

Route

Subcutaneous (s.c.) — abdomen, thigh, or upper arm

Dose

0.25-2.4 mg / weekly

Half-life

~7 days

Storage

2-8°C lyophilized; reconstituted — 28 days at 2-8°C

Dosing regimens

Standard regimens from the literature. The choice depends on what you're trying to achieve.

Protocol

Standard STEP titration

Dose: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg
Frequency: 1× weekly s.c.
Duration: 16 weeks titration + 52 weeks maintenance

Protocol

SUSTAIN (diabetes) protocol

Dose: 0.5-1.0 mg
Frequency: 1× weekly
Duration: Long-term

Side effects

See full side-effect list

Encyclopedia

Full scientific profile for Semaglutide

Calculator

What does this protocol cost per day?

Last reviewed: 6 May 2026by PeptidLabs Editorial