Side effects

Semaglutide (Ozempic, Wegovy) - side effects

Gastrointestinal (stomach-and-gut) side effects dominate the profile — nausea (44%), vomiting (24%), diarrhea (30%), and constipation (24%) in STEP 1. Most resolve over 8-12 weeks and are dose-dependent. Slow titration significantly reduces severity.

Documented effects

Sorted by severity. Source cited when published.

Pancreatitis (rare, requires discontinuation)

severe·rare

Nausea

moderate·common·STEP 1

Vomiting

moderate·common·STEP 1

Diarrhea

moderate·common·STEP 1

Constipation

mild·common·STEP 1

Reduced appetite / early satiety

mild·common

Headache

mild·uncommon

Contraindications

Family history of medullary thyroid carcinoma or MEN-2; chronic pancreatitis.

Dosing

Semaglutide dosing protocol

Encyclopedia

Full scientific profile for Semaglutide

Disclaimer: data is curated from research literature for in-vitro experiments. This is not medical advice.

Last reviewed: 6 May 2026by PeptidLabs Editorial

Side effects

Semaglutide (Ozempic, Wegovy) - side effects

Documented effects

Sorted by severity. Source cited when published.

Pancreatitis (rare, requires discontinuation)

severe·rare

Nausea

moderate·common·STEP 1

Vomiting

moderate·common·STEP 1

Diarrhea

moderate·common·STEP 1

Constipation

mild·common·STEP 1

Reduced appetite / early satiety

mild·common

Headache

mild·uncommon

Contraindications

Family history of medullary thyroid carcinoma or MEN-2; chronic pancreatitis.

Dosing

Semaglutide dosing protocol

Encyclopedia

Full scientific profile for Semaglutide

Disclaimer: data is curated from research literature for in-vitro experiments. This is not medical advice.

Last reviewed: 6 May 2026by PeptidLabs Editorial