sampleHPG maintenance
98%+ · 10mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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98%+ verified — most batches reach 99%+
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Gonadorelin
GnRH Analog | Hormonal Restoration | Pituitary Stimulation
In short
Synthetic GnRH equivalent studied in endocrine models for the regulation of gonadotropic secretion from the pituitary.
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Gonadorelin is a synthetic peptide that is structurally identical to the body's natural gonadotropin-releasing hormone (GnRH). At the molecular level, it binds to specific receptors in the pituitary gland, triggering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Researchers study this molecule in in vitro and animal models to better understand the regulation of the reproductive system and hormonal signaling. While there are approved medications containing this active ingredient for clinical use, this specific product is strictly for laboratory research purposes and is not a medical treatment for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Gonadorelin is a synthetic decapeptide that is chemically identical to endogenous gonadotropin-releasing hormone (GnRH). It acts directly on the anterior pituitary gland to stimulate the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Clinical applications primarily involve evaluating pituitary function and managing conditions related to hypogonadism or infertility. Pulsatile delivery mimics natural physiological secretion, whereas continuous administration leads to receptor downregulation.
Synthetic GnRH (Schally Nobel 1977) Pulsatile dosing stimulates LH/FSH Continuous-action desensitizes for prostate cancer therapy Diagnostic test for hypogonadism
Gonadorelin binds to specific G-protein-coupled receptors on pituitary gonadotrophs. This binding activates the phospholipase C pathway, leading to intracellular calcium mobilization and the exocytosis of LH and FSH. The frequency and amplitude of GnRH pulses dictate the relative ratio of LH to FSH secreted into the systemic circulation.
Utilized to restart endogenous hormone production after suppressive events by stimulating the pituitary to release LH and FSH.
Used as a single-dose challenge to evaluate the functional capacity and responsiveness of the anterior pituitary gland.
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Dosing must remain intermittent to prevent receptor downregulation.
Blood samples are drawn before and at specific intervals after injection to measure LH/FSH.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Administer according to specific protocol; pulsatile therapy requires strict timing, while TRT adjunct protocols often utilize morning dosing.
[Calculator]
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Standard insulin syringe 1 ml (100 marks)
Concentration
5.00mg/ml
Dose volume
0.050ml
U-100 units
5.0units
Doses per vial
40doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
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Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (10 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Administer according to specific protocol; pulsatile therapy requires strict timing, while TRT adjunct protocols often utilize morning dosing.
In clinical practice, gonadorelin is often administered via a portable infusion pump that delivers timed pulses to mimic natural hypothalamic secretion.
Important
In clinical practice, gonadorelin is often administered via a portable infusion pump that delivers timed pulses to mimic natural hypothalamic secretion.
1. Remove the 10mg gonadorelin vial and bacteriostatic water from the refrigerator and allow them to reach room temperature.
2. Wipe the rubber stoppers of both vials with an alcohol swab.
3. Draw the desired volume of bacteriostatic water into a large syringe.
4. Slowly inject the water into the gonadorelin vial, directing the flow against the glass wall.
5. Swirl the vial gently until the lyophilized powder is completely dissolved; do not shake.
Continuous or high-frequency administration will cause paradoxical suppression of the HPTA axis.
Injection site reactions including erythema and mild pain may occur.
Headaches, flushing, and mild nausea are occasionally reported following administration.
Long-term safety profile requires medical supervision to prevent receptor downregulation.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Pulsatile administration of gonadotropin-releasing hormone in hypothalamic amenorrhea
Clinical trial | Female patients | 4 weeks | Ovulation induction
Pulsatile intravenous administration of GnRH successfully induced follicular maturation and ovulation in women with severe hypothalamic amenorrhea.
Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone
Clinical trial | Male patients | 3-6 months | Testosterone normalization
Long-term pulsatile subcutaneous delivery of gonadorelin restored normal pituitary-gonadal function and induced puberty in men with idiopathic hypogonadotropic hypogonadism.
Gonadorelin stimulation test in the evaluation of pituitary-gonadal axis
Diagnostic review | Mixed cohorts | Single dose | LH/FSH response
Administration of a single 100 mcg bolus of gonadorelin reliably differentiates between hypothalamic and pituitary causes of hypogonadism based on the subsequent LH surge.
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