for fat metabolism
98%+ · 10mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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HGH Fragment 176-191
hGH Derivative | Lipolysis Stimulator | Metabolic Regulator
In short
Studied for how it may help your body break down stored fat more effectively, potentially supporting your weight loss efforts.
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HGH Fragment 176-191 is a synthetic peptide representing an isolated section (amino acids 176 to 191) of the human growth hormone molecule. At the molecular level, it interacts with fat cells to stimulate fat breakdown and inhibit the formation of new fat, without affecting insulin sensitivity or cell growth. Scientists are studying this mechanism in laboratory settings (in vitro) and animal models to better understand the processes of fat metabolism. This peptide is intended strictly for scientific research purposes and is not an approved medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
HGH Fragment 176-191 is a modified synthetic peptide derived from the C-terminal region of human growth hormone. It isolates the lipolytic properties of the full hGH molecule without inducing the associated hyperglycemic or mitogenic effects. The peptide consists of amino acids 176 through 191 of the hGH sequence. Researchers utilize this fragment to study targeted fat metabolism and beta-oxidation pathways. Subcutaneous injection is the standard delivery method to ensure systemic bioavailability.
Minimal lipolytic HGH fragment β3-adrenergic-like HSL activation Reduced lipogenesis + raised lipolysis Reference for original unmodified fragment
The peptide stimulates lipolysis and inhibits lipogenesis by interacting with beta-3 adrenergic receptors on adipocytes. This interaction upregulates hormone-sensitive lipase activity, leading to increased beta-oxidation of fatty acids in the mitochondria. Unlike full-length growth hormone, it does not bind to hGH receptors, thereby avoiding alterations in insulin sensitivity or IGF-1 production.
HGH Fragment 176-191 directly stimulates the breakdown of stored triglycerides into free fatty acids. Research indicates a preference for visceral and stubborn subcutaneous fat deposits. The peptide achieves this without the tissue-proliferating effects of full growth hormone.
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Administer morning fasted and pre-workout or before bed.
Administer morning fasted.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Administer on an empty stomach, typically first thing in the morning and optionally again before cardiovascular exercise or before bed.
[Calculator]
Change water and dose · results update in real time
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5.0marks
Standard insulin syringe 1 ml (100 marks)
Concentration
5.00mg/ml
Dose volume
0.050ml
U-100 units
5.0units
Doses per vial
40doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (10 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Administer on an empty stomach, typically first thing in the morning and optionally again before cardiovascular exercise or before bed.
Fasting is critical for optimal efficacy. Insulin spikes from food intake can blunt the lipolytic response of the peptide.
Important
Fasting is critical for optimal efficacy. Insulin spikes from food intake can blunt the lipolytic response of the peptide.
Remove the vial from the refrigerator and allow it to reach room temperature.
Wipe the rubber stopper of the peptide vial and the bacteriostatic water vial with an alcohol swab.
Draw the required volume of bacteriostatic water into the syringe.
Inject the water slowly down the inner wall of the peptide vial to avoid damaging the lyophilized powder.
Swirl the vial gently in a circular motion until the powder is completely dissolved. Do not shake.
Store the reconstituted solution in the refrigerator immediately.
Long-term safety profile not yet established. Use only under medical supervision.
May cause mild irritation, redness, or swelling at the injection site.
Does not typically affect blood glucose, but monitoring is advised for individuals with metabolic disorders.
Should not be used by pregnant or breastfeeding women.
Avoid use if you have a history of severe allergic reactions to synthetic peptides.
Compatibility
The pairings below come from research literature and established biohacker stacking patterns. Click a card for the full reasoning - when the partner is in our catalog you'll see a direct order link too.
This is a literature overview, not medical advice. Pairs not listed are not proven safe - they simply lack enough published data.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
In vitro and in vivo actions of a synthetic fragment of human growth hormone
Animal | Obese mice | 14 days | Lipolysis
Researchers administered the hGH 177-191 fragment to obese mice to evaluate lipid metabolism. The study reported significant reductions in body weight and adipose tissue mass without altering insulin sensitivity. The fragment demonstrated potent lipolytic and anti-lipogenic activity.
Phase IIb clinical trial of AOD9604 for obesity
Human | 300 subjects | 12 weeks | Weight reduction
A randomized, double-blind, placebo-controlled trial evaluated the peptide in obese individuals. Subjects receiving the optimal dose showed significant reductions in body fat and weight compared to placebo. The safety profile was excellent, with no adverse effects on glucose tolerance or IGF-1 levels.
The effects of human GH and its lipolytic fragment on lipid metabolism following chronic treatment
Animal | Mice | 14 days | Beta-3 receptor pathway
This study investigated the mechanism of action of the hGH fragment. Results indicated that the lipolytic effects are mediated through the beta-3 adrenergic receptor. Mice lacking this receptor did not experience fat loss, confirming the specific metabolic pathway utilized by the peptide.
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