HPG axis fertility
98%+ · 10mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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Kisspeptin-10
KISS1R Agonist | HPG Axis Regulator | Fertility Support
In short
10-amino acid fragment studied in neuroendocrine models as a key regulator of GnRH secretion in the hypothalamus.
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Kisspeptin-10 is a short peptide consisting of 10 amino acids that acts as a fundamental regulator of the reproductive system. At the molecular level, it binds to the KISS1 receptor in the hypothalamus, triggering a signaling cascade that stimulates the release of luteinizing and follicle-stimulating hormones. Scientists are studying this molecule in vitro and in animal models to further explore the mechanisms of the hypothalamic-pituitary-gonadal axis. This product is strictly for laboratory research purposes and is not an approved medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Kisspeptin-10 is a 10-amino-acid peptide fragment derived from the precursor protein kisspeptin-54, encoded by the KISS1 gene. It serves as the primary endogenous ligand for the G-protein coupled receptor KISS1R. The peptide functions as a critical upstream regulator of the hypothalamic-pituitary-gonadal axis. Subcutaneous administration is utilized to stimulate the natural pulsatile release of gonadotropin-releasing hormone.
Upstream regulator of GnRH neurons LH +5-8x baseline (Dhillo 2007) Restoration of hypogonadotropic hypogonadism GPR54-selective activation
Kisspeptin-10 binds directly to the KISS1 receptor located on gonadotropin-releasing hormone neurons in the hypothalamus. This binding triggers a signaling cascade that induces the secretion of gonadotropin-releasing hormone into the hypophyseal portal system. The anterior pituitary gland responds by releasing luteinizing hormone and follicle-stimulating hormone. These hormones subsequently stimulate the gonads to produce testosterone and estradiol.
Kisspeptin-10 acts upstream of gonadotropin-releasing hormone to stimulate the natural production of luteinizing hormone. This mechanism supports endogenous testosterone synthesis in males and regulates ovulatory function in females.
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Administer in the evening to mimic natural pulsatile release.
Monitor hormone levels closely to avoid receptor downregulation.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Evening administration is often preferred to align with natural nocturnal hormone pulses.
[Calculator]
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5.0marks
Standard insulin syringe 1 ml (100 marks)
Concentration
5.00mg/ml
Dose volume
0.050ml
U-100 units
5.0units
Doses per vial
40doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (10 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Evening administration is often preferred to align with natural nocturnal hormone pulses.
Kisspeptin-10 has a very short half-life, making intermittent subcutaneous injections the standard approach for mimicking physiological pulsatility.
Important
Kisspeptin-10 has a very short half-life, making intermittent subcutaneous injections the standard approach for mimicking physiological pulsatility.
1. Remove the vial from the refrigerator and allow it to reach room temperature.
2. Wipe the rubber stopper with an alcohol swab.
3. Draw 2ml of bacteriostatic water into a sterile syringe.
4. Inject the water slowly down the inner wall of the vial.
5. Swirl the vial gently until the lyophilized powder is completely dissolved. Do not shake.
Long-term safety profile not yet established. Use only under medical supervision.
May cause transient flushing or mild increases in heart rate immediately following injection.
Continuous or excessive dosing can lead to receptor downregulation and paradoxical suppression of the HPG axis.
Injection site reactions including redness and mild irritation may occur.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
Human | 6 healthy men | Single dose | LH and testosterone levels
Intravenous administration of Kisspeptin-10 elicited a rapid and robust increase in luteinizing hormone secretion. The study demonstrated that the peptide effectively stimulates the reproductive axis in human males without immediate adverse effects.
View the studyKisspeptin modulates sexual and emotional brain processing in humans
Human | 29 healthy men | Single dose | fMRI brain activity
Researchers utilized functional magnetic resonance imaging to observe brain activity following kisspeptin administration. The peptide significantly enhanced activity in limbic and paralimbic structures during the viewing of sexual and emotional images.
View the studyEffects of continuous kisspeptin administration on the hypothalamic-pituitary-gonadal axis
Animal | Rodent models | 14 days | Receptor downregulation
Continuous, non-pulsatile administration of kisspeptin-10 was shown to cause desensitization of the KISS1 receptor. This highlights the necessity of pulsatile or intermittent dosing to maintain the stimulatory effect on gonadotropin release.
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