anti-inflammatory
99%+ · 10mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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98%+ verified — most batches reach 99%+
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KPV
Anti-Inflammatory Tripeptide | Alpha-MSH Fragment
In short
Tripeptide fragment of α-MSH studied for anti-inflammatory activity via inhibition of the NF-κB pathway in tissue models.
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KPV is a short peptide consisting of three amino acids, derived from a fragment of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). At the molecular level, it penetrates cells and suppresses specific inflammatory pathways by blocking signaling in the nucleus, without causing pigmentation. Scientists are studying this peptide in laboratory settings (in vitro) and animal models for its potential anti-inflammatory and antimicrobial properties in intestinal and skin conditions. This product is intended strictly for research purposes and is not an approved medication or medical treatment for humans.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
KPV is a potent anti-inflammatory tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). This small but powerful peptide exhibits remarkable anti-inflammatory and antimicrobial properties without the pigmentation effects of full α-MSH. KPV has shown particular promise for inflammatory bowel diseases, skin conditions, and immune modulation through its ability to penetrate cells and interact directly with inflammatory signaling pathways.
NF-κB inhibition → -40-60% TNF-α in gut models (Dalmasso 2008) Antimicrobial activity against C. albicans + S. aureus α-MSH effector core without melanocortin activation Standard regenerative quartet component — quenches cytokine noise
Enters cells and inhibits inflammatory pathways at the nuclear level, particularly NF-κB signaling
Reduces circulating inflammatory markers like TNF-α and IL-6
May help balance overactive immune responses
Potential benefits for inflammatory arthritis
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Can be taken any time; some prefer morning for anti-inflammatory effects
[Calculator]
Change water and dose · results update in real time
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Visual indicator
Pull to mark 5.0
5.0marks
Standard insulin syringe 1 ml (100 marks)
Concentration
5.00mg/ml
Dose volume
0.050ml
U-100 units
5.0units
Doses per vial
40doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
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Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (10 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Can be taken any time; some prefer morning for anti-inflammatory effects
Clean vial top with alcohol pad
Add 1mL bacteriostatic water to 1mg vial (creates 1000mcg/mL)
For easier dosing: Add 2mL to 1mg vial (creates 500mcg/mL)
Gently swirl to mix - KPV dissolves easily
Solution should be clear and colorless
Label with concentration and date
Injection-site reaction
uncommon
Mild nausea (oral administration)
uncommon
Compatibility
The pairings below come from research literature and established biohacker stacking patterns. Click a card for the full reasoning - when the partner is in our catalog you'll see a direct order link too.
This is a literature overview, not medical advice. Pairs not listed are not proven safe - they simply lack enough published data.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Antimicrobial Properties Against Gut Pathogens (2022)
In vitro | Multiple bacterial strains | MIC determination
KPV showed selective antimicrobial activity against pathogenic bacteria while preserving beneficial gut microbiota, suggesting prebiotic-like properties.
KPV for Psoriasis and Dermatitis (2021)
Human cells + Animal model | Topical application | 4 weeks
Topical KPV reduced psoriatic markers by 60% and improved skin barrier function, showing promise as a steroid-sparing treatment option.
Anti-Inflammatory Mechanisms of KPV (2020)
In vitro | Various concentrations | Cell culture studies
Revealed KPV enters cells and directly inhibits NF-κB pathway, reducing TNF-α, IL-6, and other inflammatory cytokines at the transcriptional level.
KPV in Inflammatory Bowel Disease Models (2019)
Animal model | Oral and injection | 14 days | Colitis model
Demonstrated significant reduction in inflammatory markers and improved intestinal barrier function in IBD models, with both oral and injectable forms showing efficacy.
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