Anti-inflammatory · oral
99%+ · 0.5mg · Tablets · MW: 342.43
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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KPV Tablets 500 mcg × 30
α-MSH Tripeptide (Lys-Pro-Val) | Oral Anti-Inflammatory Research | IBD Focus
In short
Reduces inflammation in the body, providing targeted relief for gut and joint issues.
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Scientific review
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed on
KPV is the smallest known α-MSH-derived peptide that retains anti-inflammatory activity. The three-residue sequence (Lys-Pro-Val) corresponds to the C-terminus of α-MSH and engages melanocortin signaling along with MC1R-independent intracellular pathways. Its compact structure resists proteolytic degradation in the gut lumen — a property exploited in oral research formulations targeting intestinal inflammation.
Exceptional GI stability — oral viability Inhibits NF-κB activation Reduces TNF-α, IL-6 in inflamed tissue models Smallest peptide retaining α-MSH anti-inflammatory activity
KPV downregulates NF-κB activation in inflamed enterocytes and macrophages, reducing TNF-α, IL-6, and IL-1β output. The peptide also enters cells through PEPT1 transporter and modulates intracellular signaling independent of cell-surface MC1R, broadening its anti-inflammatory reach.
Oral KPV reduced colitis severity in DSS-induced mouse models with comparable efficacy to higher-dose α-MSH (Kannengiesser et al, Inflamm Bowel Dis 2008).
Adverse events in published research are minimal. The peptide is small, well-tolerated, and lacks signaling promiscuity at typical research doses. Pigmentation effects (a known α-MSH class signal at higher MC1R activation) have not been reported with KPV at research doses.
Compatibility
The pairings below come from research literature and established biohacker stacking patterns. Click a card for the full reasoning - when the partner is in our catalog you'll see a direct order link too.
This is a literature overview, not medical advice. Pairs not listed are not proven safe - they simply lack enough published data.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
KPV reduces experimental colitis
Mouse | Inflamm Bowel Dis 2008
Kannengiesser et al. showed that oral KPV reduced DSS-induced colitis in mice with comparable efficacy to higher-dose α-MSH.
View the study
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