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99%+ · 20mg · Tablets · MW: 373.9
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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Methylene Blue Tablets 20 mg × 30
USP Methylene Blue | Mitochondrial Electron Carrier | Nootropic & Mitochondrial Research
In short
Phenothiazine compound studied in cellular models as an alternative electron acceptor in the mitochondrial chain.
Methylene blue is one of the oldest synthetic compounds in science, characterized by its unique redox-active core. At the molecular level, it functions as an electron carrier that can interact with cellular respiration by bypassing specific pathways within the mitochondria. Researchers are actively studying it in in vitro and animal models to understand its binding to amyloid proteins and enzymes involved in neurodegenerative processes. While there are approved medical formulations of methylene blue used as specific antidotes or diagnostic agents, this specific product is research-grade and is not a medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
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Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Methylene blue is the active ingredient (methylthioninium chloride) in research-grade USP material. It is one of the oldest synthetic compounds in pharmacology — first synthesized in 1876 by Heinrich Caro. The compound's redox-active phenothiazine core can shuttle electrons in cellular respiration, lending it both diagnostic (urine staining, antidote properties) and investigational metabolic uses.
Established mitochondrial electron carrier (E°' ≈ +11 mV) FDA-approved indication: methemoglobinemia USP grade — analytically defined identity & purity Long history of research data (>140 years)
Methylene blue alternates between reduced (leuco-MB) and oxidized (MB+) forms with a midpoint potential of ~+11 mV, positioning it as an electron carrier compatible with mitochondrial complex I bypass. The compound also has MAO inhibition activity at low micromolar concentrations and binds to amyloid β oligomers in research models — making it a frequent subject in neurodegenerative research.
Methylene blue's electron-carrier activity supports research into bypassing dysfunctional complex I in aging and neurodegenerative models.
Adverse events at low doses are typically minimal: blue/green urine, transient nausea, blue staining of mucous membranes. At higher doses or with concurrent serotonergic medications, MAO inhibition can precipitate serotonin syndrome — a contraindication researchers must respect. Methylene blue is contraindicated in G6PD deficiency due to hemolysis risk.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Methylene blue improves cognitive function via mitochondria
Rodent | Neurobiol Aging 2011
Riha et al. reported memory enhancement at low-dose methylene blue with improved mitochondrial complex IV activity.
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