samplecircadian regulation
98%+ · 20mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
Verified above 98%
98%+ verified — most batches reach 99%+
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Pinealon
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
In short
Synthetic tripeptide studied in models of cognitive aging for direct transcriptional modulation in brain cells.
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Pinealon is a synthetic tripeptide composed of three amino acids, classified as a peptide bioregulator. At the molecular level, it penetrates cell nuclei to interact directly with DNA, modulating gene expression through specific cellular signaling pathways. Researchers are studying it in vitro and in animal models to observe its potential mechanisms in neuroprotection, cellular aging, and cognitive function following brain trauma. This product is strictly for research purposes and is not an approved medication or medical treatment for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement. Research suggests benefits for traumatic brain injury recovery, age-related cognitive decline, and cellular aging processes through direct gene expression modulation.
Minimal Khavinson tripeptide Neuronal apoptosis -30-50% at nanomolar Melatonin synthesis stimulation Hippocampal neuroprotection
Unique tripeptide that penetrates nuclear membranes to directly interact with DNA, modulating gene expression through histone H1.3 binding and MAPK/ERK pathway activation
Clinical study in 72 patients showed improved memory, reduced headache severity, and enhanced emotional stability in post-traumatic cerebrasthenia
Demonstrates caspase-3 suppression, ROS reduction, and excitotoxicity protection through MAPK/ERK pathway modulation
Cytokine modulation and enhanced recovery markers in clinical applications, though larger trials needed
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Morning and early afternoon for cognitive benefits
[Calculator]
Change water and dose · results update in real time
from product
Visual indicator
Pull to mark 20
20marks
Standard insulin syringe 1 ml (100 marks)
Concentration
10.00mg/ml
Dose volume
0.200ml
U-100 units
20units
Doses per vial
10doses
Recommended needle
29G / 1 ml insulin
Standard for peptide dosing — widely stocked
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (20 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Morning and early afternoon for cognitive benefits
Remove lyophilized powder and bacteriostatic water from refrigeration
Clean vial tops with alcohol swabs and allow to dry
Draw appropriate volume of bacteriostatic water into syringe
Inject water slowly down the side of the peptide vial to avoid foam
Gently swirl (do not shake) until powder dissolves completely
Store reconstituted solution in refrigerator at 2-8°C
Use within 30 days of reconstitution for optimal potency
Excellent safety profile based on 40+ years of Russian clinical experience with over 15 million patient exposures
Common side effects are minimal: injection site reactions, mild GI discomfort, headache, and fatigue
No serious systemic toxicity or organ-specific damage reported at therapeutic doses
Contraindicated in pregnancy and lactation due to limited safety data in these populations
No documented drug interactions or cytochrome P450 enzyme involvement
Quality sourcing is critical - distinguish between research-grade and pharmaceutical-grade products
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
5xFAD Alzheimer's Mouse Model (2021)
5xFAD mice | 400 μg/kg IP daily | 28 days | Dendritic spine preservation
Prevention of dendritic spine loss in established Alzheimer's model. Significant neuroprotection through MAPK/ERK pathway modulation and reduced neuroinflammation.
View the studyDiabetic Rat Model - Spatial Learning (2020)
Diabetic rats | 100 ng/kg optimal dose | 14 days | NMDA receptor expression increased
Dose-response study identifying 100 ng/kg as optimal for spatial learning improvement. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.
View the studyAntioxidant System Modulation (2019)
Cell culture and animal models | 50-100 μg daily | 14 days | ROS reduction and cellular protection
Mechanistic study demonstrating antioxidant effects at lower concentrations with cell cycle modulation at higher doses. Concentration-dependent neuroprotective effects confirmed.
View the studyInsomnia Clinical Protocol (2018)
45 patients with sleep disorders | 200 μg daily | 7 days | Sleep quality improvement
Short-term protocol showing rapid improvements in sleep onset and quality. Circadian rhythm optimization without dependency or withdrawal effects.
View the studyHuman Clinical Trial - Post-Traumatic Cerebrasthenia (2015)
72 patients aged 30-74 | 0.2mg twice daily | 20-30 days | Significant cognitive improvement
Landmark human study demonstrating improved memory, reduced headache severity and duration, and enhanced emotional stability compared to 37 controls. Primary endpoint of cognitive function met with statistical significance.
View the studyAging Study - Polymorbidity Patients (2015)
32 patients aged 41-83 | Variable dosing | 30 days | Anabolic effects and biological age improvement
Clinical assessment of biological aging indicators showing significant improvements in multiple biomarkers. Anabolic effects observed with enhanced cellular function markers.
View the study
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