for cognitive function
99%+ · 20mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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98%+ verified — most batches reach 99%+
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Semax + Selank combo
Synthetic ACTH Analog | Cognitive Enhancement Peptide
In short
Studied for how it may protect your brain and help you think more clearly, learn faster, and maintain better focus.
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Semax is a synthetic peptide that represents a modified fragment of the adrenocorticotropic hormone (ACTH). At the molecular level, it interacts with the central nervous system by stimulating the production of brain-derived neurotrophic factor (BDNF) and modulating dopamine and serotonin receptors. Scientists are investigating its potential in in vitro and animal models for neuroprotection, neuroregeneration, and its influence on cognitive processes. This product is provided strictly for laboratory research purposes and is not an approved medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, extensively studied for its nootropic, neuroprotective, and neurorestorative properties. Originally developed in Russia for stroke recovery, this brain-targeted peptide rapidly increases BDNF levels and modulates dopaminergic and serotonergic systems to enhance cognitive function, memory, and focus.
1500+ genes activated by single dose (Shadrina 2010) Clinically approved in Russia for ischemic stroke (1996) Cognitive function + neuroprotection Nasal administration for direct BBB penetration
Direct transport through olfactory epithelium and trigeminal nerves, bypassing blood-brain barrier for enhanced CNS penetration
Improved short-term and working memory performance in fatigued individuals and healthy subjects
Enhanced sustained attention during demanding cognitive tasks and prolonged work periods
Faster acquisition of new information and improved retention in educational and training settings
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Morning for cognitive enhancement, avoid evening use due to potential alertness effects
[Calculator]
Change water and dose · results update in real time
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Visual indicator
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20marks
Standard insulin syringe 1 ml (100 marks)
Concentration
10.00mg/ml
Dose volume
0.200ml
U-100 units
20units
Doses per vial
10doses
Recommended needle
29G / 1 ml insulin
Standard for peptide dosing — widely stocked
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (20 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Morning for cognitive enhancement, avoid evening use due to potential alertness effects
Semax nasal formulations come pre-mixed as 0.1% or 1% solutions
For research use, lyophilized powder can be reconstituted with sterile saline
Use preservative-free saline for nasal administration to avoid irritation
Calculate concentration based on desired mcg per spray or drop
Store reconstituted solution refrigerated and use within recommended timeframe
Always use sterile technique when preparing nasal formulations
Start with lowest effective dose (300mcg) to assess individual response
Avoid concurrent use with other intranasal medications that cause vasoconstriction
Monitor for any signs of nasal irritation, bleeding, or persistent discomfort
Do not exceed 4-week continuous use periods without medical supervision
Potential to enhance effects of stimulants - reduce other stimulant doses accordingly
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Stroke Recovery Clinical Trial (2018)
Human | 110 patients | Semax + conventional therapy | Ischemic stroke recovery
Patients recovering from ischemic stroke who received Semax showed increased BDNF levels correlated with early rehabilitation and accelerated restoration of brain functions, especially movement-related symptoms.
fMRI Default Mode Network Study (2018)
Human | 24 participants | Single dose intranasal | Brain imaging analysis
Healthy middle-aged participants showed increased fMRI default mode network activity relative to placebo, indicating enhanced neural connectivity and cognitive processing.
Neuroprotective Effects in Brain Ischemia (2014)
Animal | Rat focal ischemia model | Gene expression analysis | 3-24 hours post-treatment
Genome-wide study revealed Semax affected expression of 96 genes related to immune and vascular systems, demonstrating immunomodulating effects and influence on vascular system during ischemia.
Cognitive Enhancement in Fatigued Workers (1996)
Human | 250-1000μg intranasal | Single dose | 24-hour observation
Healthy subjects performing 8-hour work shifts showed significant improvement in attention and short-term memory, with 71% accuracy on memory tests vs 41% in controls. Effects were most pronounced when subjects were fatigued.
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