
Exercise mimetic research
98%+ · 1mg · Tablets · MW: 397.43
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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SLU-PP-332 Tablets 1 mg × 30
ERR α/β/γ Pan-Agonist | Exercise Mimetic Research | Oral Tablet Format
In short
Mimics the effects of a workout — increases physical endurance and helps the body burn fat without extra exercise.
Scientific review
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed on
SLU-PP-332 is a triple ERR agonist — the first small molecule to activate all three estrogen-related receptor isoforms with similar potency. ERRs are nuclear receptors that regulate oxidative metabolism, mitochondrial function, and fiber-type composition in skeletal and cardiac muscle. The compound is investigated as an 'exercise pill' candidate — a pharmacological mimic of the cellular adaptations driven by endurance training.
First-in-class triple ERR pan-agonist EC₅₀ vs ERRα ≈ 98 nM Murine data: improved exercise capacity Saint Louis University (Elgendy lab) — published in Nature Metabolism
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Pan-agonism at ERRα, ERRβ, and ERRγ upregulates PGC-1α coactivation targets — driving mitochondrial biogenesis, fatty-acid β-oxidation enzymes, and a shift toward slow-twitch oxidative muscle phenotype. The transcriptional program overlaps substantially with that induced by endurance exercise.
Investigated for transcriptional mimicry of endurance training adaptations — mitochondrial biogenesis, oxidative fiber shift, and fatty-acid oxidation upregulation.
Limited safety data — preclinical only. No human pharmacovigilance signal has been established. Investigators should treat the compound with full research-compound caution, including standard exclusion criteria for unstudied nuclear receptor modulators (pregnancy, hormone-sensitive conditions).
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
A small-molecule pan-ERR agonist as an exercise mimetic
Mouse | Nature Metabolism 2023
Elgendy lab reported SLU-PP-332 reproduces key transcriptional and physiological adaptations of endurance training in mouse models.
View the study
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