Comparison

SermorelinTesamorelin

Both are GHRH analogs — but Sermorelin is the minimal 1-29 fragment (Salk Institute, Roger Guillemin), while Tesamorelin is stabilized with trans-3-hexenoyl for DPP-IV resistance. Tesamorelin is FDA-approved; Sermorelin was but is withdrawn.

Spec	A Sermorelin	B Tesamorelin
Structure	GRF 1-29 (29 AA)	GRF 1-44 + trans-3-hexenoyl
Half-life	~12 minutes	~26 minutes
FDA status	Withdrawn (Geref, 2008)	Approved (Egrifta, 2010)
Visceral fat selectivity	No	Yes — 15-18% reduction over 26 weeks
Price	Lower (€39)	Higher (€79-€129)

Choose A when

Sermorelin

Classic GHRH protocols with natural pulsatile signaling. More accessible price.

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Choose B when

Tesamorelin

Visceral fat, metabolic syndrome, NAFLD research. More stable molecule.

See full profile

Verdict

Tesamorelin is the modern, stabilized successor with FDA approval and unique selectivity. Sermorelin remains the cheaper classic alternative.

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Semaglutide vs Retatrutide

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BPC-157 vs TB-500

Last reviewed: 6 May 2026by PeptidLabs Editorial

Comparison

SermorelinTesamorelin

Spec	A Sermorelin	B Tesamorelin
Structure	GRF 1-29 (29 AA)	GRF 1-44 + trans-3-hexenoyl
Half-life	~12 minutes	~26 minutes
FDA status	Withdrawn (Geref, 2008)	Approved (Egrifta, 2010)
Visceral fat selectivity	No	Yes — 15-18% reduction over 26 weeks
Price	Lower (€39)	Higher (€79-€129)

Choose A when

Sermorelin

Classic GHRH protocols with natural pulsatile signaling. More accessible price.

See full profile

Choose B when

Tesamorelin

Visceral fat, metabolic syndrome, NAFLD research. More stable molecule.

See full profile

Verdict

Tesamorelin is the modern, stabilized successor with FDA approval and unique selectivity. Sermorelin remains the cheaper classic alternative.

Other comparisons

Keep exploring

Semaglutide vs Tirzepatide

Semaglutide vs Retatrutide

Tirzepatide vs Retatrutide

BPC-157 vs TB-500

Last reviewed: 6 May 2026by PeptidLabs Editorial