What is Tesamorelin?
Tesamorelin is an -approved synthetic growth hormone-releasing hormone (
Tesamorelin — stabilized GHRH analog for HIV-associated lipodystrophy
In short
DPP-4 resistant GHRH analog studied in clinical models for the reduction of visceral adipose tissue in lipodystrophy.
Overview
Tesamorelin is an -approved synthetic growth hormone-releasing hormone (
Subcutaneous injection provides optimal bioavailability for receptor binding and pulsatile release stimulation
Molecular information
First-order decay curve at 0.4h half-life from literature. Educational only.
Research indications
Grouped by area. Each entry reflects a separate published hypothesis or clinical signal - not medical advice.
Falutz et al. (NEJM 2007, n=816) showed 15-20% reduction over 26 weeks at 2 mg s.c. daily. Subcutaneous fat unchanged.
Arthralgia (joint pain)
common·Falutz NEJM 2007
Peripheral edema
common
Paresthesia
uncommon
Injection-site reaction
common
Elevated blood glucose
uncommon
4 peer-reviewed sources
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Falutz Phase 3
Phase 3 RCT | 2 mg s.c. daily | 26 weeks | VAT -15-20% in HIV patients
NEJM · 2007
View the studyInformation about Tesamorelin is based on published scientific research and is intended for research purposes only. Not medical advice.
Products are for in vitro laboratory research only. Not approved for human consumption.
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