focus and BDNF
98%+ · 30mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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NA-Semax
ACTH Analog | Cognitive Enhancement | Neuroprotection
In short
N-acetylated version of Semax with an extended half-life, studied in neurological models for BDNF and NGF stimulation.
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N-Acetyl Semax (NA-Semax) is a synthetic peptide representing a modified version of the original Semax molecule, featuring an added acetyl group for enhanced chemical stability. At the molecular level, it modulates the expression of neurotrophic factors such as BDNF and NGF, which are involved in neuronal development and protection. Researchers study this compound in in vitro and animal models to evaluate its effects on the dopaminergic system and its antioxidant properties in brain tissue. This molecule is provided strictly for laboratory research purposes and is not an approved medication for human consumption.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
N-Acetyl Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH 4-10). It represents a structural modification of the original Russian peptide Semax, featuring an acetyl group attached to its N-terminus. This acetylation increases the peptide's resistance to enzymatic degradation in the bloodstream. The modification also enhances its lipophilicity, allowing for more efficient penetration across the blood-brain barrier. Researchers primarily study this compound for its neuroprotective properties and its ability to enhance cognitive function.
N-acetyl + amide modification extends half-life to 4-8h Once-daily dosing Improved BBB penetration via increased lipophilicity Same BDNF/NGF activation as Semax
NA-Semax rapidly elevates the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus and forebrain. It modulates the melanocortin system and influences dopaminergic and serotonergic neurotransmission without causing receptor down-regulation. The peptide also exhibits antioxidant properties by reducing lipid peroxidation in brain tissue during ischemic events.
Improves attention span, memory consolidation, and learning acquisition by modulating neurotransmitter systems and increasing neurotrophin expression.
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Administer in the morning to prevent sleep disruption.
Requires reconstitution into a sterile nasal spray bottle.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Morning or early afternoon to prevent sleep disturbances.
[Calculator]
Change water and dose · results update in real time
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20marks
Standard insulin syringe 1 ml (100 marks)
Concentration
15.00mg/ml
Dose volume
0.200ml
U-100 units
20units
Doses per vial
10doses
Recommended needle
29G / 1 ml insulin
Standard for peptide dosing — widely stocked
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (30 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Morning or early afternoon to prevent sleep disturbances.
Due to the large 30mg vial size, precise calculation of bacteriostatic water volume is critical to ensure accurate dosing.
Important
Due to the large 30mg vial size, precise calculation of bacteriostatic water volume is critical to ensure accurate dosing.
1. Remove the plastic cap from the NA-Semax vial and wipe the rubber stopper with an alcohol swab.
2. Draw the desired volume of bacteriostatic water into a sterile syringe (e.g., 10ml for a 3mg/ml concentration).
3. Inject the water slowly into the vial, aiming for the side wall to prevent foaming.
4. Swirl the vial gently until the lyophilized powder is completely dissolved. Do not shake.
5. If preparing for intranasal use, transfer the reconstituted solution to a sterile nasal spray bottle.
Long-term safety profile of the acetylated version is not fully established. Use only under medical supervision.
May cause mild stimulation or insomnia if administered late in the day.
Can cause localized irritation or redness at the subcutaneous injection site.
Intranasal administration may lead to temporary nasal irritation or dryness.
Not recommended for individuals with a history of severe psychiatric disorders without medical supervision.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Animal | 24 hours | BDNF expression
Researchers demonstrated that Semax rapidly increases BDNF protein levels and trkB receptor expression in the hippocampus, providing a mechanism for its cognitive and neuroprotective effects.
View the studyEfficacy of semax in the acute period of ischemic stroke
Human | 122 patients | 30 days | Neurological recovery
Clinical trials indicated that early administration of Semax significantly accelerated the restoration of neurological functions and reduced the severity of stroke outcomes.
View the studyThe effect of the synthetic ACTH analogue semax on the memory and attention of healthy operators
Human | Healthy adults | 24 hours | Cognitive performance
Administration of the peptide significantly improved memory and attention during highly demanding tasks, demonstrating its efficacy as a cognitive enhancer in healthy subjects.
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