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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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Selank
Synthetic Tuftsin Analog | Anxiolytic & Nootropic Peptide
In short
Synthetic tuftsin analog studied in neurological models for GABA receptor modulation and anxiolytic activity.
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Selank is a synthetic peptide developed as an analog of the naturally occurring immune peptide tuftsin. At the molecular level, it interacts with GABA receptors and influences the balance of neurotransmitters such as serotonin and dopamine, while also stimulating the production of brain-derived neurotrophic factor (BDNF). Scientists study this molecule in laboratory settings (in vitro) and animal models to understand its potential in modulating stress responses, cognitive processes, and the immune system. This product is intended strictly for scientific research purposes and is not an approved medication or therapy for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. This anxiolytic and nootropic peptide has been extensively studied for its ability to reduce anxiety, enhance cognitive function, and modulate immune responses without the side effects associated with traditional benzodiazepines. Selank works through complex interactions with GABAergic, serotonergic, and dopaminergic neurotransmitter systems, offering a unique mechanism for stress reduction and cognitive enhancement.
GABA-A indirect modulation without benzodiazepine tolerance BDNF +30-40% (Semenova 2007) Anxiety-like behavior -50% in stress models Nasal administration for CNS penetration
Allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, BDNF upregulation in hippocampus
Clinical trials demonstrate significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation, amnesia, or dependence potential
Emerging research shows effectiveness in PTSD treatment, helping stabilize stress responses and emotional regulation without cognitive impairment
Reduces anticipatory anxiety and social stress while maintaining cognitive clarity and emotional stability during challenging situations
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Morning for cognitive benefits, evening for anxiety
[Calculator]
Change water and dose · results update in real time
from product
Visual indicator
Pull to mark 10
10marks
Standard insulin syringe 1 ml (100 marks)
Concentration
2.50mg/ml
Dose volume
0.100ml
U-100 units
10units
Doses per vial
20doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (5 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Morning for cognitive benefits, evening for anxiety
Remove Selank vial from refrigeration and allow to reach room temperature for 10-15 minutes to prevent condensation
Clean vial tops with alcohol wipes using circular motion from center outward, allow to air dry completely
Calculate appropriate reconstitution volume based on desired concentration using the calculator below
Draw calculated amount of bacteriostatic water into insulin syringe, remove any air bubbles
Insert needle into Selank vial at 45-degree angle against the glass wall - do NOT inject directly into powder
Slowly inject BAC water down the side of the vial to minimize foaming and preserve peptide integrity
Remove needle and gently swirl vial - NEVER shake vigorously as this can damage the peptide structure
Allow solution to sit for 1-2 minutes if any cloudiness remains, then swirl gently until completely clear
Final solution should be clear and colorless - persistent cloudiness indicates peptide degradation
Label vial with reconstitution date and concentration, store in refrigerator immediately
Use within 30 days of reconstitution, always inspect for particles before injection
Start with lowest effective dose (250mcg) to assess individual response
Selank has excellent safety profile with minimal reported side effects
No known tolerance, dependence, or withdrawal issues reported
Can be safely combined with most medications under medical supervision
Store properly refrigerated to maintain peptide stability and potency
Use sterile injection techniques to prevent infection
Consult healthcare provider if taking multiple psychiatric medications
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
GABAergic Neurotransmission Gene Expression (2016)
Rat frontal cortex | 300 μg/kg | Real-time PCR analysis
Demonstrated Selank's modulation of 45 genes involved in neurotransmission, confirming GABAergic mechanism similar to benzodiazepines without negative effects
BDNF Expression Enhancement Study (2010)
Rat hippocampus | 250-500 μg/kg | 24-hour measurement
Found 30% increase in hippocampal BDNF levels, indicating enhanced neuroplasticity and neuroprotective effects
Generalized Anxiety Disorder Clinical Trial (2008)
Human subjects | GAD and neurasthenia | Multi-week treatment
Showed significant anxiolytic and mild nootropic effects lasting up to one week after last dose, improved quality of life without dependence
Memory Consolidation Enhancement (2007)
Rat models | Learning paradigms | Head-to-head with Piracetam
Demonstrated significant activation of learning processes in subjects with initially poor learning ability, effects apparent after first administration
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