samplefor metabolism
98%+ · 50mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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98%+ verified — most batches reach 99%+
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5-Amino-1MQ
NNMT Inhibitor | Longevity & Metabolic Enhancement
In short
Selective NNMT inhibitor studied in cellular models for its modulation of energy metabolism and NAD+ levels.
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5-Amino-1MQ is a small molecule that acts as an inhibitor of the nicotinamide N-methyltransferase (NNMT) enzyme. At the molecular level, it blocks this enzyme, which prevents the degradation of NAD+ and maintains higher levels of cellular energy and mitochondrial activity. Scientists are studying the compound in in vitro and animal models to understand its impact on cellular metabolism and aging processes. 5-Amino-1MQ is a research-grade chemical and is not an approved medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Originally developed for metabolic research, it's gaining attention for its potential anti-aging properties and ability to improve energy metabolism at the cellular level.
NNMT inhibition → +15-20% energy expenditure without diet Orally bioavailable - not a peptide Restored NAD+ levels in adipocytes Complementary to NMN/NR approach
Orally administered 5-Amino-1MQ inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining higher cellular NAD+ levels throughout the body, supporting mitochondrial function and metabolic processes
Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging
Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging
Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
With breakfast or lunch for better absorption
[Calculator]
Change water and dose · results update in real time
from product
Visual indicator
Pull to mark 20
20marks
Standard insulin syringe 1 ml (100 marks)
Concentration
25.00mg/ml
Dose volume
0.200ml
U-100 units
20units
Doses per vial
10doses
Recommended needle
29G / 1 ml insulin
Standard for peptide dosing — widely stocked
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (50 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
With breakfast or lunch for better absorption
Use pre-made capsules for convenience and accuracy (recommended)
If using powder: measure precise dose with milligram scale
Take with food to improve absorption and reduce GI effects
Maintain consistent daily timing for optimal results
Store in cool, dry place away from light and moisture
Consider cycling: 8-12 weeks on, 2-4 weeks off
No human clinical trials published - all dosing extrapolated from animal studies
38.4% oral bioavailability demonstrated in rats ( 34304009)
Start with lowest effective dose (25-50mg) to assess tolerance
Take with food to reduce potential GI effects
Monitor for any unusual symptoms and discontinue if adverse effects occur
Not recommended for pregnant or breastfeeding women
Consult healthcare provider before use, especially with existing conditions
Compatibility
The pairings below come from research literature and established biohacker stacking patterns. Click a card for the full reasoning - when the partner is in our catalog you'll see a direct order link too.
This is a literature overview, not medical advice. Pairs not listed are not proven safe - they simply lack enough published data.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Muscle Function in Aged Mice (2024)
Animal study | 10mg/kg/day SubQ | 8 weeks
40% grip strength improvement in sedentary mice, 60% with exercise. No adverse effects observed.
View the studyRat Pharmacokinetics Study (2021)
Animal PK study | Various doses | Bioavailability
Demonstrated 38.4% oral bioavailability, half-life 6.9hr (oral) and 3.8hr (IV). Supports oral administration viability.
View the studyMouse Obesity Study - Neelakantan et al. (2018)
Animal study | 20mg/kg TID (60mg/kg/day) | 11 days | n=10 mice/group
Diet-induced obese mice showed 5.1% weight loss, 30% adipocyte size reduction. Human equivalent ~5mg/kg/day using FDA allometric scaling.
View the study
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