samplefor natural GH
99%+ · 5mg · Lyophilized
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
Verified above 98%
98%+ verified — most batches reach 99%+
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Sermorelin
GHRH 1-29 Analog | Growth Hormone Releasing Hormone
In short
29-amino acid GHRH fragment studied in endocrine models for pulsatile stimulation of pituitary somatotropic secretion.
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Sermorelin is a synthetic 29-amino acid peptide that acts as an analog of growth hormone-releasing hormone (GHRH). At the molecular level, it binds to pituitary receptors to trigger the natural, pulsatile release of growth hormone. Although the molecule was historically FDA-approved for clinical use, today it is primarily investigated in in vitro and animal models to study the endocrine system. This product is strictly research-grade, intended for scientific studies, and is not a medication for human use.
Research reagent for laboratory use only. Not a medicine. For medical questions, consult a physician.
Scientific review
Written by
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed by
Борис Маринов
MSc Biochemistry & Molecular Biology
Reviewed on
Sermorelin acetate is a 29-amino acid synthetic analog of human growth hormone-releasing hormone (GHRH) originally FDA-approved in 1997 for pediatric growth hormone deficiency. Despite discontinuation in 2008 for manufacturing reasons, it maintains excellent safety profile and stimulates natural growth hormone production while preserving physiological pulsatile patterns.
Native GHRH(1-29) fragment - perfect pulsatile pattern 11-12 min half-life preserves natural feedback Standard for physiological GH rhythm research Ipamorelin partner in standard GH stack protocols
Subcutaneous injection provides optimal bioavailability with rapid onset (5-20 minutes) and physiological pulsatile GH stimulation
1.26 kg lean mass increase documented in elderly men with improved muscle strength tests
Stimulates endogenous IGF-1 production leading to muscle protein synthesis and growth
Enhanced recovery and muscle development through physiological GH stimulation
Dosing
The typical regimens you'll see in the published research - for reference when planning in vitro or in vivo experiments. Not medical advice.
Disclaimer
These are regimens discussed in the research literature, not medical advice. Consult a healthcare provider before use.
Timing
Bedtime administration 2+ hours after last meal for optimal GH response
[Calculator]
Change water and dose · results update in real time
from product
Visual indicator
Pull to mark 10
10marks
Standard insulin syringe 1 ml (100 marks)
Concentration
2.50mg/ml
Dose volume
0.100ml
U-100 units
10units
Doses per vial
20doses
Recommended needle
29G–30G / 1 ml insulin
Small volume — draw slowly; 30G works for finer precision
Cycle planner: vials for 12 weeks, cost, schedule
Opens full calculator
Results are reference values - for in vitro work. Verify against the published literature for the specific peptide.
[Step by step]
6 steps from a sealed vial to the injection. Plain language.
Peptide vial (5 mg), bacteriostatic water vial, 1 larger syringe (3-5 ml) for drawing water and 1 insulin (1 ml) for doses. Alcohol swabs for sanitizing the caps.
Wash your hands before starting.
Wipe the rubber cap of the water vial with an alcohol swab. Insert the needle, invert the vial and draw exactly 2 ml. Get the exact volume from the calculator.
Larger syringe = smaller error in volume.
Wipe the peptide vial cap. Tilt the vial 45° and release the water SLOWLY down the inner wall. Peptides are fragile — a direct stream onto the powder denatures them.
SLOWLY · DOWN THE WALL · NOT ONTO THE POWDER.
Hold the vial between both palms and swirl slowly. DO NOT shake or flip sharply — peptides break down under mechanical stress.
DON'T SHAKE. Like tea — not like a cocktail.
The powder should fully dissolve. The solution is clear, no visible particles. If cloudy or with sediment — discard (wrong water or bad batch).
Clear = OK. Cloudy = discard.
With the insulin syringe draw the exact marks from the calculator. Swab the skin (abdomen 5 cm around the navel, thigh, or buttock), pinch a fold, insert at 45-90° and inject slowly.
Rotate sites every injection to avoid lipohypertrophy.
Schedule
Bedtime administration 2+ hours after last meal for optimal GH response
Allow sermorelin vial to reach room temperature before reconstitution
Clean vial top with alcohol swab and allow to dry
Inject 3mL bacteriostatic water slowly against vial wall (not directly onto powder)
Gently swirl vial in circular motion - do not shake vigorously to avoid foaming
Allow to sit for 2-3 minutes until powder completely dissolves into clear solution
Store reconstituted solution at 2-8°C and use within 10-30 days depending on formulation
Inject subcutaneously at 45-degree angle rotating between lower abdomen, thigh, and upper arm sites
Monitor thyroid function - 6.5% develop hypothyroidism requiring hormone replacement
Check levels monthly initially, then every 3-6 months long-term
Injection site reactions occur in 16.7% of patients but are generally mild
Contraindicated in active malignancy, pituitary tumors, and pregnancy
Compatibility
The pairings below come from research literature and established biohacker stacking patterns. Click a card for the full reasoning - when the partner is in our catalog you'll see a direct order link too.
This is a literature overview, not medical advice. Pairs not listed are not proven safe - they simply lack enough published data.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Nasal Administration Study (1990s)
Adults | 30+ μg/kg intranasal | Acute | 69% patient preference over injection
Clinical study demonstrating effective nasal delivery with patient preference benefits and direct absorption via nasal capillaries
View the studySynergistic Effects with GHRP-2 (Clinical)
Adults | GHRH+GHRP-2 | Acute | 54-fold vs 20-fold GH increase
Study demonstrating significant synergistic effects when combining GHRH analogs with growth hormone releasing peptides
View the studyFDA Approval Study - Pediatric GH Deficiency (1996)
Children | 30 mcg/kg daily | 36 months | Height velocity 4.1→8.0 cm/year
Pivotal Geref International Study Group trial with 110 prepubertal GH-deficient children demonstrating sustained efficacy through 36 months of treatment
View the studyPharmacokinetic Profile Study (1996)
Adults | Single dose | Acute | 11-12 minute half-life, 6% bioavailability
Comprehensive pharmacokinetic analysis showing rapid clearance and bioavailability profile for subcutaneous administration
View the studyAdult Anti-Aging Study - Elderly Men (1992)
Men aged 60-78 | Variable doses | 6 weeks | Doubled 12-hour GH release
Landmark study by Corpas et al. demonstrating reversal of age-related GH/IGF-1 decline with improvements approaching younger men
View the studyBody Composition in Elderly (1992)
Men 60-78 years | Multiple doses | 6 weeks | 1.26 kg lean mass increase
Study by Vittone et al. showing improved muscle strength tests, decreased systolic blood pressure, and enhanced body composition
View the study
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