Research peptides · For laboratory and scientific research in vitro · Not medications · Not approved for consumption · Adults only (18+)
HGH 191AA (Somatropin)
In plain language
191AA (Somatropin) — recombinant growth hormone with the full 191-amino acid sequence. Bypasses the pituitary and delivers directly via the JAK2/STAT5 cascade.
For researchers
Somatropin (191AA) is a recombinant form of human growth hormone with the full 191-amino acid sequence, identical to endogenous pituitary . Production is via rDNA technology in Escherichia coli — Genentech's pioneering work (1981) made somatropin the first commercial rDNA pharmaceutical. Mechanistically binds GHR ( receptor) on the cell surface, dimerizes it and activates the JAK2/STAT5 signaling cascade. STAT5 induces synthesis in the liver — is the secondary mediator responsible for anabolic and anti-apoptotic effects in peripheral tissues. Beyond the pathway, has direct effects: lipolysis in adipocytes via hormone-sensitive lipase (especially visceral), hepatic glycogenolysis and stimulation of chondrocytes in epiphyseal plates. Rudman's classic study (NEJM 1990) documents body composition redistribution in older men after 6 months of therapy. Unlike / peptides that stimulate endogenous release, somatropin bypasses the pituitary and delivers exogenous directly. This is a stronger but less physiological signal. Half-life s.c. ~3.5 hours. Storage: 2-8°C lyophilized; reconstituted — 14 days at 2-8°C, protected from light and without freezing.
Scientific literature
Other peptides
Information about HGH 191AA (Somatropin) is based on published scientific research and is intended for research purposes. Not medical advice.
Products related to this peptide are for in vitro laboratory research only. Not approved for human consumption.
