Antiparasitic research
99%+ · 5mg · Tablets · MW: 875.1
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This product is sold strictly for in lab conditions (in vitro) research purposes. Not approved for human consumption.
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Ivermectin Tablets 5 mg × 30
Macrocyclic Lactone | Glutamate-Gated Cl⁻ Channel Agonist | Antiparasitic Research
In short
Clears the body of parasites and is actively researched for supporting the immune system and cellular health.
Scientific review
Калина Тодорова
Magister Pharmaciae, MSc Pharmacy
Reviewed on
Ivermectin is a mixture of 22,23-dihydroavermectin B1a (≥80%) and B1b (≤20%) — semi-synthetic macrocyclic lactones with broad-spectrum antiparasitic activity. The compound is poorly absorbed by mammalian cells due to P-glycoprotein efflux at the blood-brain barrier, providing the selectivity that underpins its safety profile.
WHO Essential Medicines List since 1987 Nobel Prize 2015 (Ōmura, Campbell — antiparasitic discovery) >3 billion human doses administered globally Strong oral bioavailability — established pharmacokinetics
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Ivermectin selectively binds glutamate-gated chloride channels in invertebrate neurons and muscle cells, opening them and producing chloride influx that hyperpolarizes the cell. The result is paralysis. Mammalian glutamate-gated chloride channels do not exist in nervous tissue accessible at therapeutic doses, providing the species-selective therapeutic window.
Effective against Onchocerca, Strongyloides, Wuchereria, scabies (Sarcoptes), and head lice. Mass drug administration programs (MectizanⓇ) have controlled onchocerciasis in West Africa for decades.
Adverse events at therapeutic doses are typically mild and self-limited — dizziness, nausea, transient hypotension. The Mazzotti reaction (skin/eye inflammation) can occur when high parasite loads die rapidly. Neurological signs at supratherapeutic doses have been documented; the safety margin in mammals is wide due to P-glycoprotein-mediated CNS exclusion.
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Ivermectin and antiparasitic mass drug administration
Review | Trends Parasitol
Comprehensive review of ivermectin's role in onchocerciasis control programs — the largest mass drug administration effort in history.
View the study
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