MOTS-c — mitochondrial peptide for metabolic regulation
In short
Mitochondrially derived peptide studied for activating AMPK signaling and modulating insulin sensitivity.
Overview
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial genome. It acts as a mitohormone that regulates metabolic homeostasis, enhances insulin sensitivity, and promotes longevity. MOTS-c operates through the Folate-AICAR-AMPK pathway and can translocate to the nucleus under metabolic stress to regulate gene expression.
MOTS-c operates through the Folate-AICAR-AMPK pathway, inhibiting the folate cycle and leading to AMPK activation. Under metabolic stress, it translocates to the nucleus and binds to stress-response transcription factors (NRF2, ATF1/ATF7) to regulate gene expression involved in metabolism, antioxidant response, and cellular stress adaptation.
Molecular information
Research indications
Grouped by area. Each entry reflects a separate published hypothesis or clinical signal - not medical advice.
Lee et al. (Cell Metab 2015) - AMPK activation improves glucose tolerance + reduces visceral fat in 7-14 days.
Понася се добре в проучвания върху животни с минимални странични ефекти. Следете кръвната захар при употреба на лекарства за диабет. Дългосрочните данни за безопасност при хора са ограничени. Може да причини леки реакции на мястото на инжектиране. Не се препоръчва по време на бременност или кърмене. Забранен е от WADA за състезатели. Спрете употребата при: тежки алергични реакции или анафилаксия; повтарящи се епизоди на хипогликемия (под 50 mg/dL); постоянни тежки реакции на мястото на инжектиране; необяснима загуба на тегло над 10% от първоначалното; всякакви притеснителни симптоми.
3 peer-reviewed sources
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Lee - HFD model
Animal | 5 mg/kg | 14 days | AMPK activation, insulin sensitivity +
Cell Metab · 2015
View the studyInformation about MOTS-c is based on published scientific research and is intended for research purposes only. Not medical advice.
Products are for in vitro laboratory research only. Not approved for human consumption.
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