P21 (CCK-8 fragment) — neurotrophic peptide for neuronal regeneration
In short
Studied for how it may help your brain grow new cells, potentially supporting your memory, learning, and overall mental clarity.
Overview
P21 (also known as P021) is a synthetic tetrapeptide derived from the biologically active region of human ciliary neurotrophic factor (CNTF). Featuring an adamantylated glycine modification for enhanced blood-brain barrier penetration and metabolic stability, P21 promotes neurogenesis, enhances synaptic plasticity, and has shown significant cognitive benefits in preclinical models of Alzheimer's disease, traumatic brain injury, and age-related cognitive decline.
Intranasal administration exploits the direct anatomical connection between nasal mucosa and brain via olfactory and trigeminal nerve pathways. This provides rapid CNS delivery while minimizing systemic exposure. P21's lipophilic adamantane modification enhances mucosal absorption and subsequent brain penetration.
Molecular information
Research indications
Grouped by area. Each entry reflects a separate published hypothesis or clinical signal - not medical advice.
Bolognin et al. (J Neurochem 2014) - +40-60% and -50-70% amyloid-β-induced cell death.
Използвайте стерилно оборудване за назален спрей. Почистете носните пътища преди приложение. Пептидът може да причини временно дразнене на носа. Липсват клинични изпитвания върху хора. Започнете с по-ниски дози за оценка на поносимостта. Консултирайте се с медицински специалист преди употреба. Всички ползи се основават на предклинични и анекдотични данни. Спрете приложението при продължително дразнене на носа или кървене. Прекратете употребата при тежко главоболие, необичайни неврологични симптоми или значителни промени в настроението.
3 peer-reviewed sources
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
Bolognin
In vitro | various | various | BDNF +40-60%, neuronal survival
J Neurochem · 2014
View the studyInformation about P21 is based on published scientific research and is intended for research purposes only. Not medical advice.
Products are for in vitro laboratory research only. Not approved for human consumption.
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