SS-31 (Elamipretide) — mitochondria-targeted peptide for cardiolipin stabilization
In short
Cell-penetrating tetrapeptide studied for stabilizing cardiolipin and optimizing inner mitochondrial membrane function.
Overview
SS-31, also known as Elamipretide or Bendavia, is a small aromatic-cationic tetrapeptide that selectively targets mitochondria. Unlike traditional antioxidants, SS-31 specifically binds to cardiolipin in the inner mitochondrial membrane, protecting it from oxidative damage and improving cellular energy production. This unique mechanism makes it particularly promising for age-related conditions, heart disease, and mitochondrial disorders.
Selectively binds to cardiolipin in inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport chain function
Molecular information
Research indications
Grouped by area. Each entry reflects a separate published hypothesis or clinical signal - not medical advice.
Stealth BioTherapeutics MMPOWER (Phase 3) - 40 mg s.c. daily improved 6MWT by 50-100 m over 24 weeks.
Клиничните изпитвания показват отличен профил на безопасност. Не са докладвани значителни странични ефекти при терапевтични дози. Може да предизвика леки реакции на мястото на инжектиране. Наблюдавайте за алергични реакции, които са много редки. Настоящите данни сочат безопасност при продължителна употреба. Няма известни лекарствени взаимодействия. Сигнали за спиране: Тежки реакции на мястото на инжектиране. Признаци на алергична реакция като обрив или затруднено дишане. Необичайна умора или слабост поради парадоксална реакция. Всякакви сърдечно-съдови симптоми. Тежко главоболие или промени в зрението.
3 peer-reviewed sources
References
Links to peer-reviewed publications on PubMed, cited in the peptide's scientific profile.
MMPOWER
Phase 3 | 40 mg s.c. | 24 weeks | 6MWT +50-100 m
various · 2020
View the studyInformation about SS-31 is based on published scientific research and is intended for research purposes only. Not medical advice.
Products are for in vitro laboratory research only. Not approved for human consumption.
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